Lef1 expression in fibroblasts maintains developmental potential in adult skin to regenerate wounds

Quan M Phan, Gracelyn M Fine, Lucia Salz, Gerardo G Herrera… — eLife 2020

ABSTRACT Scars are a serious health concern for burn victims and individuals with skin conditions associated with wound healing. Here, we identify regenerative factors in neonatal murine skin that transforms adult skin to regenerate instead of only repairing wounds with a scar, without perturbing…

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Type 1 versus type 3 neovascularization in pigment epithelial detachments associated with age-related macular degeneration after anti-vascular endothelial growth factor therapy: a prospective study

X Chen, M Al-Sheikh, CK Chan, AH Hariri, P Abraham… – RETINA, 2016

Purpose: To evaluate the response to aflibercept therapy for Type 1 and Type 3 neovascularization in pigment epithelial detachments associated with treatment-naive, neovascular age-related macular degeneration. Methods: In this multicentered, …

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Integration of Growth Factor Gene Delivery with Collagen‐Triggered Wound Repair Cascades using Collagen‐Mimetic Peptides

MA Urello, KL Kiick, MO Sullivan – Bioengineering & Translational Medicine, 2016

ABSTRACT Growth factors (GFs) play vital roles in wound repair. Many GF therapies have reached clinical trials, but success has been hindered by safety concerns and a lack of efficacy. Previously, we presented an approach to produce protein factors in wound beds …

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Transforming growth factor beta 1 increases collagen content, and stimulates procollagen I and tissue inhibitor of metalloproteinase-1 production of dental pulp cells

PS Lin, HH Chang, CY Yeh, MC Chang, CP Chan… – Journal of the Formosan …, 2016

Methods Pulp cells were exposed to TGF-β1 with/without pretreatment and coincubation by 1, 4-diamino-2, 3-dicyano-1, 4-bis (o-aminophenyl mercapto) butadiene (U0126; a mitogen-activated protein kinase kinase [MEK]/extracellular signal-regulated kinase [ERK] inhibitor …

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Evaluation of Epidermal Growth Factor-Incorporating Skin Care Product in Culture Experiment Using Human Fibroblasts

A Yamamoto, H Ohno, Y Kuroyanagi – Open Journal of Regenerative Medicine, 2016

This study aimed to investigate the potential of a skin care product composed of hyaluronic acid (HA) and collagen (Col) sponge containing epidermal growth factor (EGF), vitamin C derivative (VC), glucosylceramide (GC), poly (γ-glutamic acid)(PGA), and argentine (Arg). ...

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